Alcohols and ethers
Introducing reactions of alcohols and ethers.
Acid-catalyzed pinacol rearrangement:
Steps:
- A hydroxyl group is protonated, which leaves in the form water molecule to produce a carbocation;
- The neighboring methyl group migrates to form a new carbocation, and the other hydroxyl group turns into a protonated carbonyl simultaneously;
- Proton dissociates from carbonyl, forming the rearranged product.