Chen-Hui Yuan

Chen-Hui Yuan

PhD student, 2019-2024

State Development and Investment Group Co., LTD.

袁晨晖 (Chen-Hui Yuan)

Chen-Hui was born in Ji’an, Jiangxi in January 1998. He studied chemistry in China Agricultural University from 2015 to 2019, and then joined Jiao’s group at Tsinghua University as a graduate student.

His doctoral pursuits centered on the utilization of SOHP ligands in palladium(II)-catalyzed, coordination-assisted enantioselective C(sp3)-H functionalization reactions of diverse simple substrates. Moreover, he achieved the isolation, characterization, and subsequent transformation of pivotal palladacycle intermediates with ligand-induced chirality, thereby elucidating the stereochemical processes and ligand effects upon the reactions.

Chen-Hui obtained his PhD degree in June, 2024. After graduation, he transitioned into the corporate realm by joining the State Development and Investment Corporation (SDIC) as a management trainee.

Interests
  • Transition-metal catalysis
  • Ligand design
  • Reaction mechanism
Education
  • PhD in chemistry, 2024

    Tsinghua University

  • BSc in applied chemistry, 2019

    China Agricultural University

Publications

  1. Chen-Hui Yuan, Lei Jiao* "Chiral Ligands for Palladium-Catalyzed Coordination-Assisted Enantioselective C(sp3)-H Functionalization Reactions (Invited Review).
    手性配体在钯催化配位辅助对映选择性C(sp3)-H键官能团化反应中的应用(中文综述)" Chin. J. Org. Chem. 2025, 45, 602-619.
  2. Chen-Hui Yuan, Xiao-Xia Wang, Keyun Huang, Lei Jiao* "Unveiling the Mechanistic Role of Chiral Palladacycles in Pd(II)-Catalyzed Enantioselective C(sp3)-H Functionalization." Angew. Chem. Int. Ed. 2024, 63, e202405062.
  3. Chen-Hui Yuan, Lei Jiao* "Ligand-Enabled Palladium(II)-Catalyzed γ-C(sp3)−H Arylation of Primary Aliphatic Amines." Org. Lett. 2024, 26, 29-34.
  4. Chen-Hui Yuan, Xiao-Xia Wang, Lei Jiao* "Ligand-Enabled Pd(II)-Catalyzed Enantioselective β-C(sp3)-H Arylation of Aliphatic Tertiary Amides." Angew. Chem. Int. Ed. 2023, 62, e202300854.
  5. Yu-Jie Wang, Chen-Hui Yuan, De-Zhao Chu, Lei Jiao* "Regiocontrol in the Oxidative Heck Reaction of Indole by Ligand-Enabled Switch of the Regioselectivity-Determining Step." Chem. Sci. 2020, 11, 11042-11054.
  6. Zongyang Li, Shiyang Xu, Baoliang Huang, Chen-Hui Yuan, Wenxu Chang, Bin Fu, Lei Jiao*, Peng Wang, Zhenhua Zhang* "Pd-Catalyzed Carbonylation of Acyl Azides." J. Org. Chem. 2019, 84, 9497-9508.