We recently achieved ortho-alkylation of iodoarenes utilizing a dual-ligand catalytic system that effectively combines palladium/olefin ligand cooperative catalysis with reversible C(sp2)–I reductive elimination enabled by a bulky trialkylphosphine …
Enantioselective C(sp3)-H functionalization reactions have emerged as a powerful and straightforward strategy in the construction of chiral molecules. Palladium, highlighted by its remarkable reactivity, versatility, and functional group tolerance, …
The synthesis of complex polysubstituted aromatic molecules from simple precursors is a central goal in organic chemistry. In this study, we developed an approach for the ortho-alkylation of iodoarenes utilizing a dual ligand catalytic system. By …
TThe Catellani reaction, also known as the Pd/norbornene catalysis, is a potent method for synthesizing multisubstituted arenes through the ortho-functionalization/ipso-termination process of haloarenes. This chemistry relies heavily on the formation …
Palladium-catalyzed enantioselective C(sp3)-H functionalization reactions has attracted considerable attention due to its ability for the synthesis of enantiomerically enriched molecules and stimulation of novel retrosynthetic disconnections. …
We have developed thio-cyclopentene ligands for Pd(II) catalysis, which could substitute norbornene or its derivatives to promote Catellani-type reactions. These ligands enabled generic palladium/olefin cooperative catalysis for the first time, and …
Amines are common scaffolds in bioactive molecules as well as building blocks for chemical synthesis. Despite significant advances in palladium-catalyzed C(sp3)−H functionalization of amines over the past decades, it remains challenging to perform …
Amide is a widespread functional group in organic and bioorganic chemistry, and it is valuable to achieve stereoselective C(sp3)-H functionalization in amide molecules. Pd(II) catalysis has been prevalently used in the C-H activation chemistry in the …
The Catellani reaction, i.e. the Pd/NBE cooperative catalysis, has been evolved into a versatile approach to multisubstituted arenes via the ortho-functionalization/ipso-termination process of a haloarene. Despite significant advances over the past …
Engineering of molecular catalysts in homogeneous catalysis enables new catalytic modes, leading to efficient synthetic transformations. In this regard, design of ligands for transition-metal catalysis has played a major role. In transition metal …