Pyridine is a crucial heterocyclic compound in organic chemistry. Typically, the pyridine motif behaves as an N-nucleophile and an electron-deficient aromatic ring. Transforming the pyridine ring into an electron-rich system that exhibits reactivity …
The incorporation of perfluoroalkyl groups into molecules leads to unique properties, and perfluoroalkylation reagents play a vital role in facilitating this process. Although various types of perfluoroalkylation reagents have been developed, the …
The traditional method for the preparation of alkylboronic esters involves transition metal catalysis or transition metal-free methods relying on single electron transfer. Each method relies on the suitable choice of catalyst or electron transfer …
Photoinduced electron transfer is an efficient approach to single-electron reduction of organic molecules for their activation. A variety of molecular photoredox systems have been developed for this purpose, whereas only a few of them exhibit potent …
Carbon-fluorine bond activation reaction of the trifluoromethyl group represent an important approach to fluorine-containing molecules. While selective defluorofunctionalization reactions of CF3-containing substrates have been achieved by invoking …
Pyridine is an important structural motif that is prevalent in natural products, drugs, and materials. Methods that functionalize and derivatize pyridines have gained significant attention. Recently, a large number of transition-metal-free reactions …
Umpolung of pyridine hydroboration was achieved by the reaction between pyridine and diboron(4) with a base and a proton source. , The first inverse hydroboration of pyridine with a diboron(4) compound and a …
Utilizing pyridine catalysis, we developed a visible-light-induced transition-metal-free radical borylation reaction of unactivated alkyl bromides that features a broad substrate scope and mild reaction conditions. Mechanistic studies revealed a …
The preparation of arylboronates from unactivated aryl chlorides in a transition-metal-free manner is rather challenging. There are only few examples to achieve this goal by using ultraviolet irradiation. Based on the mechanistic understanding of the …
The combination of diboron, pyridine and base serves as an efficient source of structurally well-defined super electron donors. , Single-electron transfer is an important process in organic chemistry, in which a …